Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high metabolic demand. With the limited protein-folding capacity of the ER, tumor cells often suffer from more ER stre...

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Hlavní autoři: Suh, Dong Hoon, Kim, Mi-Kyung, Kim, Hee Seung, Chung, Hyun Hoon, Song, Yong Sang
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Inc 2012
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499662/
https://ncbi.nlm.nih.gov/pubmed/23050960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1749-6632.2012.06739.x
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