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Unfolded protein response to autophagy as a promising druggable target for anticancer therapy
The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high metabolic demand. With the limited protein-folding capacity of the ER, tumor cells often suffer from more ER stre...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Inc
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3499662/ https://ncbi.nlm.nih.gov/pubmed/23050960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1749-6632.2012.06739.x |
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