The impact of cow's milk-mediated mTORC1-signaling in the initiation and progression of prostate cancer

Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth signaling. The nutrient-sensitive kinase mTORC1 is upregulated in nearly 100% of advanced human PCas. Oncogenic mTORC1 signaling activates key sub...

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Hlavní autoři: Melnik, Bodo C, John, Swen Malte, Carrera-Bastos, Pedro, Cordain, Loren
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499189/
https://ncbi.nlm.nih.gov/pubmed/22891897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-7075-9-74
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