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Why does the G117H mutation considerably improve the activity of human butyrylcholinesterase against sarin? Insights from QM/MM-FE calculations
Human butyrylcholinesterase (BChE) is recognized as the most promising bioscavenger for organophosphorus (OP) warfare nerve agents. The G117H mutant of human BChE has been identified as a potential catalytic bioscavenger with a remarkably improved activity against OP nerve agents such as sarin, but...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3499032/ https://ncbi.nlm.nih.gov/pubmed/23092211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3009246 |
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