Restoration of Vision in the pde6β-deficient Dog, a Large Animal Model of Rod-cone Dystrophy

Defects in the β subunit of rod cGMP phosphodiesterase 6 (PDE6β) are associated with autosomal recessive retinitis pigmentosa (RP), a childhood blinding disease with early retinal degeneration and vision loss. To date, there is no treatment for this pathology. The aim of this preclinical study was t...

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Bibliographische Detailangaben
Hauptverfasser: Petit, Lolita, Lhériteau, Elsa, Weber, Michel, Le Meur, Guylène, Deschamps, Jack-Yves, Provost, Nathalie, Mendes-Madeira, Alexandra, Libeau, Lyse, Guihal, Caroline, Colle, Marie-Anne, Moullier, Philippe, Rolling, Fabienne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498794/
https://ncbi.nlm.nih.gov/pubmed/22828504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.134
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