Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells.

We have constructed cell-specific cytotoxic agens by covalently coupling the A chain from diphtheria toxin or ricin toxin to monoclonal antibody directed against a colorectal carcinoma tumor-associated antigen. Antibody 1083-17-1A was modified by attachment of 3-(2-pyridyldithio)propionyl or cystami...

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Bibliographische Detailangaben
Hauptverfasser: Gilliland, D G, Steplewski, Z, Collier, R J, Mitchell, K F, Chang, T H, Koprowski, H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1980
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC349879/
https://ncbi.nlm.nih.gov/pubmed/6933502
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