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Preparation of bifunctional isocyanate hydroxamate linkers: Synthesis of carbamate and urea tethered polyhydroxamic acid chelators

Two novel bifunctional N-methylhydroxamate-isocyanate linkers 20 and 21 were prepared in good yield and high purity from the corresponding amine salts using a biphasic reaction with phosgene. The facile ring opening reaction of N-Boc lactams using the anion of O-benzylhydroxylamine gave the protecte...

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書誌詳細
主要な著者: Fernando, Rasika, Shirley, Jonathan M., Torres, Emilio, Jacobs, Hollie K., Gopalan, Aravamudan S.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498463/
https://ncbi.nlm.nih.gov/pubmed/23162172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2012.09.025
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