Multiple Novel Alternative Splicing Forms of FBXW7α Have a Translational Modulatory Function and Show Specific Alteration in Human Cancer

FBXW7 acts as a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of FBXW7 expression, which could be partially attributed by the genomic deletion or mutation of FBXW7 locus, is frequently observed in various human cancers. However, the mechanisms regulating FBXW...

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Detalhes bibliográficos
Main Authors: Liu, Yueyong, Ren, Shancheng, Castellanos-Martin, Andres, Perez-Losada, Jesus, Kwon, Yong-Won, Huang, Yurong, Wang, Zeran, Abad, Mar, Cruz-Hernandez, Juan J., Rodriguez, Cesar A., Sun, Yinghao, Mao, Jian-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498124/
https://ncbi.nlm.nih.gov/pubmed/23166673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049453
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