Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens

Inositol monophosphatase (IMPase) catalyses the hydrolysis of inositol monophosphate to inositol and is crucial in the phosphatidylinositol (PI) signalling pathway. Lithium, which is the drug of choice for bipolar disorder, inhibits IMPase at therapeutically relevant plasma concentrations. Both mous...

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Detaylı Bibliyografya
Asıl Yazarlar: Singh, Nisha, Halliday, Amy C., Knight, Matthew, Lack, Nathan A., Lowe, Edward, Churchill, Grant C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: International Union of Crystallography 2012
Konular:
Structural Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497969/
https://ncbi.nlm.nih.gov/pubmed/23027737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112035191
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