Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens

Inositol monophosphatase (IMPase) catalyses the hydrolysis of inositol monophosphate to inositol and is crucial in the phosphatidylinositol (PI) signalling pathway. Lithium, which is the drug of choice for bipolar disorder, inhibits IMPase at therapeutically relevant plasma concentrations. Both mous...

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Detalhes bibliográficos
Main Authors: Singh, Nisha, Halliday, Amy C., Knight, Matthew, Lack, Nathan A., Lowe, Edward, Churchill, Grant C.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2012
Assuntos:
Structural Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497969/
https://ncbi.nlm.nih.gov/pubmed/23027737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112035191
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