Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens

Inositol monophosphatase (IMPase) catalyses the hydrolysis of inositol monophosphate to inositol and is crucial in the phosphatidylinositol (PI) signalling pathway. Lithium, which is the drug of choice for bipolar disorder, inhibits IMPase at therapeutically relevant plasma concentrations. Both mous...

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Hlavní autoři: Singh, Nisha, Halliday, Amy C., Knight, Matthew, Lack, Nathan A., Lowe, Edward, Churchill, Grant C.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2012
Témata:
Structural Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497969/
https://ncbi.nlm.nih.gov/pubmed/23027737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112035191
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