Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Mevinolin, a fungal metabolite, was isolated from cultures of Aspergillus terreus. The structure and absolute configuration of mevinolini and its open acid form, mevinolinic acid, were determined by a combination of physical techniques. Mevinolin was shown to be 1,2,6,7,8,8a-hexahydro-beta, delta-di...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Alberts, A W, Chen, J, Kuron, G, Hunt, V, Huff, J, Hoffman, C, Rothrock, J, Lopez, M, Joshua, H, Harris, E, Patchett, A, Monaghan, R, Currie, S, Stapley, E, Albers-Schonberg, G, Hensens, O, Hirshfield, J, Hoogsteen, K, Liesch, J, Springer, J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1980
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349746/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6933445/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.7.3957
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