Production of (R)-3-Quinuclidinol by E. coli Biocatalysts Possessing NADH-Dependent 3-Quinuclidinone Reductase (QNR or bacC) from Microbacterium luteolum and Leifsonia Alcohol Dehydrogenase (LSADH)

We found two NADH-dependent reductases (QNR and bacC) in Microbacterium luteolum JCM 9174 (M. luteolum JCM 9174) that can reduce 3-quinuclidinone to optically pure (R)-(−)-3-quinuclidinol. Alcohol dehydrogenase from Leifsonia sp. (LSADH) was combined with these reductases to regenerate NAD(+) to NAD...

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Hlavní autoři: Isotani, Kentaro, Kurokawa, Junji, Itoh, Nobuya
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Diversity Preservation International (MDPI) 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497340/
https://ncbi.nlm.nih.gov/pubmed/23202966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms131013542
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