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The Inactivation of Intrinsic Antibiotic Resistance Determinants Widens the Mutant Selection Window for Quinolones in Stenotrophomonas maltophilia

We have determined that the mutational inactivation of the SmeDEF efflux pump and the SmQnr quinolone resistance protein widens the mutant selection windows for ofloxacin and ciprofloxacin of Stenotrophomonas maltophilia by reducing their MICs. Resistant mutants arising from a strain lacking SmeDEF...

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Detalhes bibliográficos
Main Authors: García-León, Guillermo, Sánchez, María B., Martínez, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497180/
https://ncbi.nlm.nih.gov/pubmed/23006759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01558-12
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