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Activation-induced deaminase contributes to the antibody-independent role of B cells in the development of autoimmunity

B cells contribute to autoimmunity both as secretors of pathogenic antibodies and through the activation of autoreactive T cells. B cells and antibodies acquire higher affinity to self-antigen through a process known as immunoglobulin hypermutation or SHM. The contribution of SHM to pathogenic antib...

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Detalhes bibliográficos
Main Authors: Jiang, Chuancang, Zhao, Ming-Lang, Waters, Katherine M., Diaz, Marilyn
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496248/
https://ncbi.nlm.nih.gov/pubmed/22559231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/08916934.2012.682668
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