Humanization of an anti-CCR4 antibody that kills Cutaneous T-Cell Lymphoma cells and abrogates suppression by T-regulatory cells

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of neoplastic disorders characterized by clonally derived and skin-homing malignant T-cells that express high level of chemokine receptor CCR4, which is associated with their skin-homing capacity. CCR4 is also highly expressed on T-regulatory...

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Main Authors: Chang, De-Kuan, Sui, Jianhua, Geng, Shusheng, Muvaffak, Asli, Bai, Mei, Fuhlbrigge, Robert C., Lo, Agnes, Yammanuru, Anuradha, Hubbard, Luke, Sheehan, Jared, Campbell, James J., Zhu, Quan, Kupper, Thomas S., Marasco, Wayne A.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496034/
https://ncbi.nlm.nih.gov/pubmed/22869555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0278
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