Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors

BACKGROUND: Sickle cell disease (SCD) is associated with both acute vaso-occlusive painful events as well as chronic pain syndromes, including heightened sensitivity to touch. We have previously shown that mice with severe SCD (HbSS mice; express 100% human sickle hemoglobin in red blood cells; RBCs...

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Bibliografiske detaljer
Main Authors: Garrison, Sheldon R, Kramer, Audra A, Gerges, Nashaat Z, Hillery, Cheryl A, Stucky, Cheryl L
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495672/
https://ncbi.nlm.nih.gov/pubmed/22963123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-62
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