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An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals
BACKGROUND: The APOBEC3 (A3) genes play a key role in innate antiviral defense in mammals by introducing directed mutations in the DNA. The human genome encodes for seven A3 genes, with multiple splice alternatives. Different A3 proteins display different substrate specificity, but the very basic qu...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3495650/ https://ncbi.nlm.nih.gov/pubmed/22640020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-12-71 |
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