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Benzodiazepine treatment induces subtype-specific changes in GABA(A) receptor trafficking and decreases synaptic inhibition

Benzodiazepines potentiate γ-aminobutyric acid type A receptor (GABA(A)R) activity and are widely prescribed to treat anxiety, insomnia, and seizure disorders. Unfortunately, clinical use of benzodiazepines (BZs) is severely limited by tolerance. The mechanisms leading to BZ tolerance are unknown. B...

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Bibliographische Detailangaben
Hauptverfasser: Jacob, Tija C., Michels, Guido, Silayeva, Liliya, Haydon, Julia, Succol, Francesca, Moss, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494928/
https://ncbi.nlm.nih.gov/pubmed/23091016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204994109
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