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Functional inactivation of Rb sensitizes cancer cells to TSC2 inactivation induced cell Death
We showed previously that inactivation of TSC2 induces death in cancer cells lacking the Retinoblastoma (Rb) tumor suppressor under stress conditions, suggesting that inactivation of TSC2 can potentially be used as an approach to specifically kill cancers that have lost WT Rb. As Rb is often inactiv...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494767/ https://ncbi.nlm.nih.gov/pubmed/23022476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.09.016 |
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