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Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation
One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent st...
保存先:
| 第一著者: | |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494387/ https://ncbi.nlm.nih.gov/pubmed/22785560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.98 |
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