Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum (SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but their role in relation to AE is indistinct. Filaggrin is an epithelial barrier protein with a central role in...

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Autori principali: Janssens, Michelle, van Smeden, Jeroen, Gooris, Gert S., Bras, Wim, Portale, Guiseppe, Caspers, Peter J., Vreeken, Rob J., Hankemeier, Thomas, Kezic, Sanja, Wolterbeek, Ron, Lavrijsen, Adriana P., Bouwstra, Joke A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Patient-Oriented and Epidemiological Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494247/
https://ncbi.nlm.nih.gov/pubmed/23024286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P030338
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