Major Histocompatibility Complex Class II(+) Invariant Chain Negative Breast Cancer Cells Present Unique Peptides that Activate Tumor-specific T Cells from Breast Cancer Patients

The major histocompatibility complex (MHC) class II-associated Invariant chain (Ii) is present in professional antigen presenting cells where it regulates peptide loading onto MHC class II molecules and the peptidome presented to CD4(+) T lymphocytes. Because Ii prevents peptide loading in neutral s...

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Autores principales: Chornoguz, Olesya, Gapeev, Alexei, O'Neill, Michael C., Ostrand-Rosenberg, Suzanne
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494186/
https://ncbi.nlm.nih.gov/pubmed/22942358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.019232
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