Multi-level evidence that circulating CK18 is a biomarker of tumour burden in colorectal cancer

BACKGROUND: Circulating total cytokeratin 18 (tCK18) and/or caspase cleaved cytokeratin 18 (cCK18) (measured by M65 and M30 enzyme-linked immunosorbent assays (ELISAs), respectively) are used as pharmacodynamic (PD) biomarkers of epithelial cell death in clinical trials. Having validated these ELISA...

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Bibliographic Details
Main Authors: Greystoke, A, Dean, E, Saunders, M P, Cummings, J, Hughes, A, Ranson, M, Dive, C, Renehan, A G
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
Subjects:
Molecular Diagnostics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493762/
https://ncbi.nlm.nih.gov/pubmed/22996610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.416
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