Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasia

We explored the association of HPV16 DNA methylation with age, viral load, viral persistence, and risk of incident and prevalent high grade CIN (CIN2+) in serially collected specimens from the Guanacaste, Costa Rica cohort. 273 exfoliated cervical cell specimens (diagnostic and pre-diagnostic) were...

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Hauptverfasser: Mirabello, Lisa, Schiffman, Mark, Ghosh, Arpita, Rodriguez, Ana C., Vasiljevic, Natasa, Wentzensen, Nicolas, Herrero, Rolando, Hildesheim, Allan, Wacholder, Sholom, Scibior-Bentkowska, Dorota, Burk, Robert D., Lorincz, Attila T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493709/
https://ncbi.nlm.nih.gov/pubmed/22847263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27750
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