Hormone Therapy, Estrogen Metabolism, and Risk of Breast Cancer in the Women’s Health Initiative Hormone Therapy Trial

BACKGROUND: In the Women’s Health Initiative Hormone Trials (WHI-HT), breast cancer risk was increased with estrogen plus progestin (E+P) but not with unopposed estrogen (E-alone). We hypothesized that E+P would preferentially metabolize to 16α-hydroxyestrone (16α-OHE1) rather than 2-hydroxyestrone...

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Main Authors: Mackey, Rachel H., Fanelli, Theresa J., Modugno, Francesmary, Cauley, Jane A., McTigue, Kathleen M., Brooks, Maria Mori, Chlebowski, Rowan T., Manson, JoAnn E., Klug, Thomas, Kip, Kevin E., Curb, J. David, Kuller, Lewis H.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493689/
https://ncbi.nlm.nih.gov/pubmed/22933427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-12-0759
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