Myocardial Chemokine Expression and Intensity of Myocarditis in Chagas Cardiomyopathy Are Controlled by Polymorphisms in CXCL9 and CXCL10

BACKGROUND: Chronic Chagas cardiomyopathy (CCC), a life-threatening inflammatory dilated cardiomyopathy, affects 30% of the approximately 8 million patients infected by Trypanosoma cruzi. Even though the Th1 T cell-rich myocarditis plays a pivotal role in CCC pathogenesis, little is known about the...

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Autors principals: Nogueira, Luciana Gabriel, Santos, Ronaldo Honorato Barros, Ianni, Barbara Maria, Fiorelli, Alfredo Inácio, Mairena, Eliane Conti, Benvenuti, Luiz Alberto, Frade, Amanda, Donadi, Eduardo, Dias, Fabrício, Saba, Bruno, Wang, Hui-Tzu Lin, Fragata, Abilio, Sampaio, Marcelo, Hirata, Mario Hiroyuki, Buck, Paula, Mady, Charles, Bocchi, Edimar Alcides, Stolf, Noedir Antonio, Kalil, Jorge, Cunha-Neto, Edecio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493616/
https://ncbi.nlm.nih.gov/pubmed/23150742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001867
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