Tim-3-Expressing CD4(+) and CD8(+) T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions

T-cell immune responses modulated by T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) during Mycobacterium tuberculosis (Mtb) infection in humans remain poorly understood. Here, we found that active TB patients exhibited increases in numbers of Tim-3-expressing CD4(+) and CD8(+)...

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Main Authors: Qiu, Yueqin, Chen, Jianbo, Liao, Hongying, Zhang, Yan, Wang, Hua, Li, Shaoyuan, Luo, Yanfen, Fang, Danyun, Li, Guobao, Zhou, Boping, Shen, Ling, Chen, Crystal Y., Huang, Dan, Cai, Jiye, Cao, Kaiyuan, Jiang, Lifang, Zeng, Gucheng, Chen, Zheng W.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493466/
https://ncbi.nlm.nih.gov/pubmed/23144609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002984
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