K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan- or oxaliplatin-based chemotherapy

Background: CRC caused more than 600,000 estimated deaths in 2008. Dysregulated signaling through the RAS/RAF/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway due to mutations in K-Ras and B-Raf are common events in CRC. Methods: Incidence of mutat...

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Bibliografiske detaljer
Main Authors: Stec, Rafał, Bodnar, Lubomir, Charkiewicz, Radosław, Korniluk, Jan, Rokita, Marta, Smoter, Marta, Ciechowicz, Marzena, Chyczewski, Lech, Nikliński, Jacek, Kozłowski, Wojciech, Szczylik, Cezary
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Clinical Study
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493430/
https://ncbi.nlm.nih.gov/pubmed/22909976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.21813
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