Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives

BACKGROUND AND PURPOSE: The use of tubulin-binding compounds, which act in part by inhibiting tumour angiogenesis, has become an integral strategy of tumour therapy. Recently, tubulysins were identified as a novel class of natural compounds of myxobacterial origin, which inhibit tubulin polymerizati...

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Detalhes bibliográficos
Main Authors: Rath, S, Liebl, J, Fürst, R, Ullrich, A, Burkhart, JL, Kazmaier, U, Herrmann, J, Müller, Rolf, Günther, M, Schreiner, L, Wagner, E, Vollmar, AM, Zahler, S
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492986/
https://ncbi.nlm.nih.gov/pubmed/22595030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02037.x
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