Serum Glutamate Levels Correlate with Gleason Score and Glutamate Blockade Decreases Proliferation, Migration, and Invasion and Induces Apoptosis in Prostate Cancer Cells

PURPOSE: During glutaminolysis, glutamine is catabolized to glutamate and incorporated into citric acid cycle and lipogenesis. Serum glutamate levels were measured in patients with primary prostate cancer (PCa) or metastatic castrate-resistant PCa (mCRPCa) to establish clinical relevance. The effect...

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Hauptverfasser: Koochekpour, Shahriar, Majumdar, Sunipa, Azabdaftari, Gissou, Attwood, Kristopher, Scioneaux, Ray, Subramani, Dhatchayini, Manhardt, Charles, Lorusso, Giovanni D., Willard, Stacey S., Thompson, Hillary, Shourideh, Mojgan, Rezaei, Katayoon, Sartor, Oliver, Mohler, James L., Vessella, Robert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492499/
https://ncbi.nlm.nih.gov/pubmed/23072969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1308
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