Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity

Advancing age leads to significant decline in immune functions. IL-21 is produced primarily by T follicular helper (Tfh) cells and is required for effective immune cell functions. Here we compared the induction of IL-21 in aged and young subjects. Our investigation demonstrates that CD4+T cells from...

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Hlavní autoři: Agrawal, Anshu, Su, Houfen, Chen, Justine, Osann, Kathryn, Agrawal, Sudhanshu, Gupta, Sudhir
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2012
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492228/
https://ncbi.nlm.nih.gov/pubmed/23064011
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