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Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymus

Age-related decline in the generation of T cells is associated with two primary lymphoid organs, the bone marrow (BM) and thymus. Both organs contain lympho-hematopoietic progenitor/stem cells (LPCs) and non-hematopoietic stromal/niche cells. Murine model showed this decline is not due to reduced qu...

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Detalhes bibliográficos
Main Authors: Sun, Liguang, Brown, Robert, Chen, Shande, Zhuge, Qichuan, Su, Dong-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492225/
https://ncbi.nlm.nih.gov/pubmed/23047952
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