Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain

Thioredoxin-1 (Trx1) is an endogenous dithiol reductant and antioxidant that was shown to be decreased in Alzheimer's disease (AD) neurons. A truncated form of Trx1, thioredoxin 80 (Trx80), was reported to be secreted from monocytes having cytokine activity. Here, we show that Trx80 is present...

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Autori principali: Gil-Bea, Francisco, Akterin, Susanne, Persson, Torbjörn, Mateos, Laura, Sandebring, Anna, Avila-Cariño, Javier, Gutierrez-Rodriguez, Angel, Sundström, Erik, Holmgren, Arne, Winblad, Bengt, Cedazo-Minguez, Angel
Natura: Artigo
Lingua:Inglês
Pubblicazione: WILEY-VCH Verlag 2012
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491839/
https://ncbi.nlm.nih.gov/pubmed/22933306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201462
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