Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF

Hypoxic microenvironment plays an important role in determining stem cell fates. However, it is controversial to which direction between self-renewal and differentiation the hypoxia drives the stem cells. Here, we investigated whether a short exposure to hypoxia (termed ‘hypoxic-priming’) efficientl...

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Detalhes bibliográficos
Main Authors: Lee, Sae-Won, Jeong, Han-Kyul, Lee, Ji-Young, Yang, Jimin, Lee, Eun Ju, Kim, Su-Yeon, Youn, Seock-Won, Lee, Jaewon, Kim, Woo Jean, Kim, Kyu-Won, Lim, Jeong Mook, Park, Jong-Wan, Park, Young-Bae, Kim, Hyo-Soo
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491825/
https://ncbi.nlm.nih.gov/pubmed/22821840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201101107
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