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An amplified sensitivity arising from covalent modification in biological systems.

The transient and steady-state behavior of a reversible covalent modification system is examined. When the modifying enzymes operate outside the region of first-order kinetics, small percentage changes in the concentration of the effector controlling either of the modifying enzymes can give much lar...

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Detalles Bibliográficos
Autores principales: Goldbeter, A, Koshland, D E
Formato: Artigo
Lenguaje:Inglês
Publicado: 1981
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC349147/
https://ncbi.nlm.nih.gov/pubmed/6947258
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