Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3

BACKGROUND: The TCF7L2 transcription factor is linked to a variety of human diseases, including type 2 diabetes and cancer. One mechanism by which TCF7L2 could influence expression of genes involved in diverse diseases is by binding to distinct regulatory regions in different tissues. To test this h...

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Detalhes bibliográficos
Main Authors: Frietze, Seth, Wang, Rui, Yao, Lijing, Tak, Yu Gyoung, Ye, Zhenqing, Gaddis, Malaina, Witt, Heather, Farnham, Peggy J, Jin, Victor X
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491396/
https://ncbi.nlm.nih.gov/pubmed/22951069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-9-r52
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