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Bisphosphonate-induced gastrointestinal mucosal injury is mediated by mitochondrial superoxide production and lipid peroxidation

Bisphosphonates such as alendronate and risedronate are commonly used for the treatment of postmenopausal osteoporosis. They have the gastrointestinal adverse effects such as erosions and ulcers in stomach and small intestine. However, the detailed biological mechanism remains to be elucidated. Sinc...

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Detalhes bibliográficos
Main Authors: Nagano, Yumiko, Matsui, Hirofumi, Shimokawa, Osamu, Hirayama, Aki, Nakamura, Yukio, Tamura, Masato, Rai, Kanho, Kaneko, Tsuyoshi, Hyodo, Ichinosuke
Formato: Artigo
Idioma:Inglês
Publicado em: the Society for Free Radical Research Japan 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491244/
https://ncbi.nlm.nih.gov/pubmed/23170047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3164/jcbn.12-41
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