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PAK in Alzheimer disease, Huntington disease and X-linked mental retardation
Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines. Neurodegenerative diseases such as Alzheimer disease (AD), where both PAK1 and PAK3 are dysregulated, may share f...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3490962/ https://ncbi.nlm.nih.gov/pubmed/23162743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cl.21602 |
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