The Nonantibiotic Small Molecule Cyslabdan Enhances the Potency of β-Lactams against MRSA by Inhibiting Pentaglycine Interpeptide Bridge Synthesis

The nonantibiotic small molecule cyslabdan, a labdan-type diterpene produced by Streptomyces sp. K04-0144, markedly potentiated the activity of the β-lactam drug imipenem against methicillin-resistant Staphylococcus aureus (MRSA). To study the mechanism of action of cyslabdan, the proteins that bind...

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Main Authors: Koyama, Nobuhiro, Tokura, Yuriko, Münch, Daniela, Sahl, Hans-Georg, Schneider, Tanja, Shibagaki, Yoshio, Ikeda, Haruo, Tomoda, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490914/
https://ncbi.nlm.nih.gov/pubmed/23166602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048981
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