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Vaccine Candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans

We evaluated the role of vaccine candidate surface proteins, PhtD and PhtE as antigens with functional importance for Streptococcus pneumoniae (pneumococci) in adherence to nasopharyngeal (D562) and lung (A549) epithelial cell lines. Comparing TIGR4 to PhtD and PhtE-deleted isogenic mutants, a 40% (...

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Detalles Bibliográficos
Main Authors: Khan, M. Nadeem, Pichichero, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490617/
https://ncbi.nlm.nih.gov/pubmed/22349524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.02.023
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