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A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions
We have created two neuron-specific mouse models of mitochondrial electron transport chain deficiencies involving defects in complex III (CIII) or complex IV (CIV). These conditional knockouts (cKOs) were created by ablation of the genes coding for the Rieske iron–sulfur protein (RISP) and COX10, re...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3490513/ https://ncbi.nlm.nih.gov/pubmed/22914734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds350 |
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