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Design of Non-Standard Insulin Analogs for the Treatment of Diabetes Mellitus
Structure-based protein design has enabled the engineering of insulin analogs with improved pharmacokinetic and pharmacodynamic properties. Exploiting classical structures of zinc insulin hexamers, the first insulin analog products focused on destabilization of subunit interfaces to obtain rapid-act...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3490047/ https://ncbi.nlm.nih.gov/pubmed/22983891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11892-012-0318-z |
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