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Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts

BACKGROUND: Antiangiogenic agents that disrupt the vascular endothelial growth factor pathway have been demonstrated to normalize tumor vasculature and improve tumor oxygenation in some studies and to induce hypoxia in others. The aim of this preclinical study was to investigate the effect of suniti...

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Detalhes bibliográficos
Main Authors: Gaustad, Jon-Vidar, Simonsen, Trude G, Leinaas, Marit N, Rofstad, Einar K
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489843/
https://ncbi.nlm.nih.gov/pubmed/22947392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-388
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