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Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication

Asthmatics are more susceptible to influenza infections, yet mechanisms mediating this enhanced susceptibility are unknown. Influenza virus hemagglutinin (HA) protein binds to sialic acid residues on the host cells. HA requires cleavage to allow fusion of the viral HA with host cell membrane, which...

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Detalhes bibliográficos
Main Authors: Kesic, Matthew J, Hernandez, Michelle, Jaspers, Ilona
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489803/
https://ncbi.nlm.nih.gov/pubmed/22992220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-82
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