Replication of BIN1 association with Alzheimer’s disease and evaluation of genetic interactions

The most recent late-onset Alzheimer’s disease (LOAD) genome-wide association study revealed genome-wide significant association of two new loci: rs744373 near BIN1 (p=1.6×10(−11)) and rs597668 near EXOC3L2/BLOC1S3/MARK4 (p=6.5×10(−9)). We have genotyped these variants in a large (3,287 LOAD, 4,396...

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Autori principali: Carrasquillo, Minerva M., Belbin, Olivia, Hunter, Talisha A., Ma, Li, Bisceglio, Gina D., Zou, Fanggeng, Crook, Julia E., Pankratz, V. Shane, Sando, Sigrid B., Aasly, Jan O., Barcikowska, Maria, Wszolek, Zbigniew K., Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., Morgan, Kevin, Younkin, Steven G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489170/
https://ncbi.nlm.nih.gov/pubmed/21321396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-101932
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