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Novel germline CDK4 mutations in patients with head and neck cancer
BACKGROUND: Cyclin-dependent kinase 4 (CDK4) together with its regulatory subunit cyclin D1, governs cell cycle progression through G(1) phase. Cyclin-dependent kinase inhibitors, including p16(INK4A) in turn regulate CDK4. In particular, deregulation of the p16/CDK4/cyclin D1 complex has been estab...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488972/ https://ncbi.nlm.nih.gov/pubmed/22932448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1897-4287-10-11 |
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