The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis

BACKGROUND: Production of the chemokine CCL2 by cells of the neurovascular unit (NVU) drives critical aspects of neuroinflammation. Suppression of CCL2 therefore holds promise in treating neuroinflammatory disease. Accordingly, we sought to determine if the compound bindarit, which inhibits CCL2 syn...

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Detalhes bibliográficos
Main Authors: Ge, Shujun, Shrestha, Bandana, Paul, Debayon, Keating, Carolyn, Cone, Robert, Guglielmotti, Angelo, Pachter, Joel S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488971/
https://ncbi.nlm.nih.gov/pubmed/22788993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-171
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