Ex-vivo transduced autologous skin fibroblasts expressing human Lim Mineralization Protein-3 efficiently form new bone in animal models

Local gene transfer of the human LIM Mineralization Protein (LMP), a novel intracellular positive regulator of the osteoblast differentiation program, can induce efficient bone formation in rodents. In order to develop a clinically relevant gene therapy approach to facilitate bone healing, we have u...

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Main Authors: Lattanzi, Wanda, Parrilla, Claudio, Fetoni, Annarita, Logroscino, Giandomenico, Straface, Giuseppe, Pecorini, Giovanni, Stigliano, Egidio, Tampieri, Anna, Bedini, Rossella, Pecci, Raffaella, Michetti, Fabrizio, Gambotto, Andrea, Robbins, Paul D., Pola, Enrico
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488859/
https://ncbi.nlm.nih.gov/pubmed/18633445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2008.116
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