CD24 is an effector of HIF-1 driven primary tumor growth and metastasis

Hypoxia drives malignant progression in part by promoting accumulation of the oncogenic transcription factor HIF-1α in tumor cells. Tumor aggressiveness also relates to elevation of the cancer stem cell-associated membrane protein CD24, which has been causally implicated in tumor formation and metas...

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Autors principals: Thomas, Shibu, Harding, Michael, Smith, Steven C., Overdevest, Jonathan B., Nitz, Matthew D., Frierson, Henry F., Tomlins, Scott A., Kristiansen, Glen, Theodorescu, Dan
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488144/
https://ncbi.nlm.nih.gov/pubmed/22926560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3666
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