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Activation of Cannabinoid Receptor Type 1 (Cb1r) Disrupts Hepatic Insulin Receptor Signaling via Cyclic AMP-response Element-binding Protein H (Crebh)-mediated Induction of Lipin1 Gene

Activation of hepatic cannabinoid 1 receptor (Cb1r) signaling has been implicated in the development of phenotypes associated with fatty liver, hypertriglyceridemia, and insulin resistance. In the current study, we have elucidated the critical role of endoplasmic reticulum-bound transcription factor...

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Autors principals: Chanda, Dipanjan, Kim, Yong-Hoon, Kim, Don-Kyu, Lee, Min-Woo, Lee, Su-Yeon, Park, Tae-Sik, Koo, Seung-Hoi, Lee, Chul-Ho, Choi, Hueng-Sik
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488074/
https://ncbi.nlm.nih.gov/pubmed/22989885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377978
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