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Allosteric Communication between the Pyridoxal 5′-Phosphate (PLP) and Heme Sites in the H(2)S Generator Human Cystathionine β-Synthase
Human cystathionine β-synthase (CBS) is a unique pyridoxal 5′-phosphate (PLP)-dependent enzyme that has a regulatory heme cofactor. Previous studies have demonstrated the importance of Arg-266, a residue at the heme pocket end of α-helix 8, for communication between the heme and PLP sites. In this s...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488039/ https://ncbi.nlm.nih.gov/pubmed/22977242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.414706 |
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