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Structural and Functional Characterization of VanG d-Ala:d-Ser Ligase Associated with Vancomycin Resistance in Enterococcus faecalis

d-Alanyl:d-lactate (d-Ala:d-Lac) and d-alanyl:d-serine ligases are key enzymes in vancomycin resistance of Gram-positive cocci. They catalyze a critical step in the synthesis of modified peptidoglycan precursors that are low binding affinity targets for vancomycin. The structure of the d-Ala:d-Lac l...

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Detalhes bibliográficos
Main Authors: Meziane-Cherif, Djalal, Saul, Frederick A., Haouz, Ahmed, Courvalin, Patrice
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488035/
https://ncbi.nlm.nih.gov/pubmed/22969085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.405522
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